The long and short of it: long-chain fatty acids and long-term outcomes for premature infants.
نویسندگان
چکیده
Dietary supplementation with longchain polyunsaturated fatty acids (LCPUFA) for preterm infants has been a matter of intense interest since the early 1990s. The initial clinical studies from that time period demonstrated that adding omega-3 LCPUFA (mainly from marine oils) to the infant formulas of the day resulted in improved visual and retinal outcomes for preterm infants fed the supplemented formulas compared with those fed nonsupplemented formulas. Until that time, formulas intended for preterm infants were devoid of LCPUFA. These and other studies were designed to provide formula-fed preterm infants a dietary exposure to LCPUFA similar to that of the human milk–fed preterm infant; that is, ∼20 mg/kg per day or 0.2% to 0.3% of total fatty acids as docosahexaenoic acid (DHA), which represents the median daily intake of most infants in resource-rich countries. These trials showed that LCPUFA supplementation of preterm infant formulas was safe. They also reported on the efficacy of various short-term outcomes of neural maturity in some subgroups of infants. These findings resulted in the universal supplementation of infant formulas for preterm infants by the year 2000. Thus, current neonatal feeding practices provide premature infants roughly the same dietary intake of LCPUFA regardless of whether they are fed their mother’s milk, preterm infant formula, or a combination of both.
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ورودعنوان ژورنال:
- Pediatrics
دوره 135 6 شماره
صفحات -
تاریخ انتشار 2015